A New Approach to the Chronology of Biblical History from Abraham to Samuel.  112 pages. $29.95. Click for details. The Exodus Happened 2450 B.C.  94 pages. $29.95. Click for details. Noah Aging: Cause and Cure.  143 pages. Free download. Click for details. Click for a quick introduction to vitamin MePA. Click to purchase vitamin MePA. Click to give a gift of support.
  Advanced Search
Sign Up

  • Facebook, Instagram: @AgingCauseAndCure
  • Twitter: @AgingCauseCure



Biblical Chronology Dendrochronology Radiocarbon Dating     Mt. Sinai Jericho Ai The Exodus Noah's Ark Imhotep/Joseph Vitamin MePA

Contact Us

books newsletters time charts

Vitamin MePA Testimonials

Optimal Dose

by Gerald Aardsma; March 3, 2018

In Aging: Cause & Cure (see book link in banner bar above) I pointed out that the determination of the optimal dose of vitamin MePA was likely to be a lengthy process.

Though the chemical compound corresponding to vitamin C, ascorbic acid, was discovered in the 1930's, the optimal dose is still an ongoing debate today. …

Determination of the optimal dose of any vitamin is not a trivial exercise. MePA is no exception. Determination of the optimal dose of MePA is likely to be an area of active research for years.

The purpose of this Summary Report webpage is to keep abreast of the latest information relevant to this topic.


A broad foundation and framework for the optimal dose of vitamin MePA was presented in chapter 14 of Aging: Cause & Cure. Chapter 14 concluded as follows:

Taken together, these estimates suggest that the optimal dose of MePA will likely be found to be within a factor of ten of a few micrograms per day.

There seems to me to be less reason for concern about overdosing than there is for underdosing with MePA. Mice show no adverse effects, even at very high doses, as previously mentioned. For example, I have maintained one group of 36 ICR (Harlan) female mice at 100 milligrams MePA per liter in their drinking water for seven months now. This is equivalent to a human dose of roughly 250,000 micrograms per day. These mice are just over a year old. So far, there has been no mortality nor any sign of adverse health effects in any mouse of this group.

Water-soluble vitamins, especially those which are small acids, do not generally pose a risk of overdose, as any excess is readily removed from the body by the kidneys.

This property seems to be shared, as expected, by MePA. Tolerance to overdosing with MePA in humans seems to have been demonstrated by the full life spans enjoyed by both Noah and Seth who lived through the Spike, as well as by the first three post-Flood generations who were born during the Spike. All of these individuals appear to have been subject to very high MePA doses during the Spike, and these high doses seem to have done them significant good and no harm, at least as far as longevity is concerned.

Meanwhile, underdosing is known to produce the ravages of "old age," dramatically reducing potential life expectancy.

We tend to fear the unknown. The MePA vitamin is unknown relative to "aging," with which we have become comfortably familiar. But make no mistake, "aging" is the thing to be feared in this instance—it is the dread disease.

Prudence seems to me to call for immediate adoption of a 2 microgram MePA per day intake regimen for adults, pending recommended daily allowance refinement based upon further research.

Frequently Asked Questions

What is the normal dose for someone using Dr. Aardsma's Vitamin MePA Dietary Supplement?

Normal use is 1 drop per day, which gives a dose of 2 ug MePA/day.

Why are some users taking more than 1 drop per day?

At this stage in our understanding of the vitamin, the main guiding principle is that it is better to take too much than it is to take too little. This is moderated by the possibility of unknown negative side effects at too high a dose.

The normal dose of 1 drop per day was designed to give the best compromise between the possibility of unknown negative side effects at too high a dose and the known, ultimately fatal, aging disease resulting from too low a dose.

Initial impetus for dosing at more than 1 drop per day came from individuals dealing with serious health issues. These individuals hoped, by increasing the dose, to avoid impending, unpleasant, and expensive medical interventions. Increasing the dose of MePA seemed likely to increase the rate of any healing MePA might provide. Individuals facing serious medical intervention viewed potential negative side effects at higher doses as a risk they were more than willing to take.

By the time these situations arose, I had already experimented on myself at 2 and then at 3 drops per day. My purpose had been merely to look for negative side effects, of which none were ever encountered. My experience in this regard was subsequently corroborated by those individuals facing serious medical interventions who chose to increase their dose.

As more and more people have taken Dr. Aardsma's Vitamin MePA Dietary Supplement at 1 drop per day, with no reports of any negative side effects, concerns about negative side effects at 2 drops per day have diminished. This has led to the current situation in which some normally healthy individuals are taking 2 drops per day.

Should I be taking 2 drops per day?

My initial dose was 1 ug MePA per day (equal to 1/2 drop). This dose cured my CIDP, cleared up several chronic skin infections, improved sleep, speeded healing, and improved skin moisture. Clearly, this dose is already efficacious. But the possibility remains that it is not high enough to completely cure aging.

To improve the probability of being at a high enough dose to completely cure aging, Dr. Aardsma's Vitamin MePA Dietary Supplement is formulated to provide users with twice my initial dose when it is used at 1 drop per day. Obviously, this dose is not guaranteed to be high enough either. But because laboratory work giving more empirical guidance on the optimum dose seems likely to yield results before too many more months have passed, any shortfall should have minimal practical effect on the longevity of normally healthy individuals.

For normally healthy individuals, whether to take 1 or 2 drops per day is a matter of personal preference at present. If 1 drop per day seems to be working well for you, there is probably not much to be gained by changing to 2 drops per day, but there is probably no harm in doing so either.

For the very elderly, or for individuals facing serious medical situations, even more than 2 drops per day seems a reasonable choice at present, especially at the start of dosing when the vitamin's body reservoir is being filled.

The following question was added September 25, 2018.

What should I do if I miss my daily dose?

Based both on theory and the little data available on this at the present time, it does not appear to be a good idea to miss your daily dose of vitamin MePA.

I explained the the current thinking behind this in a letter to my daughter, Jennifer, published in the "Correspondence" section of this website, on the "vitamin MePA" page.

… both you and Steve had bad results following a brief lapse in taking the vitamin. I strongly recommend that you not allow any such lapse in the future.

We don't yet know the optimum daily dose of vitamin MePA (we are diligently working on this in the lab), but we do know that zero is too little. In Noah's day, everybody got a dose of vitamin MePA every time they took a drink of water. This makes it possible that the residence time of the MePA molecule in the body is very short. (In Aging: Cause and Cure [see page 52, footnote 19] I noted the possibility that one or more metabolites of MePA, rather than MePA itself, may be responsible for the very long biological half-life associated with the anti-aging function of the vitamin. Other functions of the vitamin may have no such long-lived metabolites buffering them in the absence of the MePA molecule.) If the residence time of the MePA molecule in the body is on the order of a day, and you stop taking it for a few days, your body will rapidly enter a deficient state, with negative health consequences the likely result.

A deliberate effort to explore what happens when dose is decreased was recently made by Joey Contreras, Sr. He observed definite negative health consequences when he decreased his dose.

On 01 May 2018, I intentionally decreased vitamin MePA from 3 to 2 drops daily to monitor any changes to BPH [Benign Prostatic Hyperplasia] symptoms, energy level and sleep quality. On 11 May, my BPH symptoms recurred, but were mild. Over the next 2 days my symptoms returned to pre-vitamin MePA severity. My energy level and my speed while running, which had improved very much since starting the vitamin, slowly decreased. BPH symptoms continued to worsen, so on 15 May I started taking 4 drops daily. BPH symptoms slowly decreased and by 01 June they had returned to minimal. It took about 1 week for energy level, running and speed to return. I did not notice any change in sleep quality during time of taking 2 drops daily.

If I accidentally missed my daily dose of Dr. Aardsma's Vitamin MePA Dietary Supplement, I would take the missed dose as soon as I remembered, up to and including the time of my normal dose the next day (i.e., if I only remembered the next day, I would double up the dose on that day).

  Copyright © 2019 Aardsma Research & Publishing. All rights reserved.